The Surprising Clinical Benefits of MDMA for Trauma

Could a Psychedelic Drug Be the Next Big Thing in Treatment?

Ryan Howes

The times they are a-changin’ over at the Drug Enforcement Agency. After 50-odd years of clamping down on hallucinogenics like LSD, the DEA is quietly okaying the release of MDMA, another psychoactive schedule-I drug (street-named Ecstasy or Molly) for Food and Drug Administration–approved psychotherapeutic trials.

For decades, legalization advocates and healers have trumpeted the therapeutic benefits of the prosocial, fear-reducing MDMA—which, with its stimulation of hormones and neurotransmitters like oxytocin and dopamine, is known as “the love drug.” But psychopharmacologists were on the fence about its clinical benefits until a few years ago, when studies of the MDMA-assisted psychotherapeutic work of Michael Mithoefer were released.

Mithoefer, a clinical faculty member at the Medical University of South Carolina, has demonstrated remarkable early results using MDMA as a therapist-supervised treatment for chronic PTSD. His work is being approved by the FDA and could eventually clear a path for MDMA treatment clinics specializing in trauma. We caught up with Mithoefer between research trials to learn more.


RH: How did you get interested in psychedelic treatment? Was it part of your clinical training?

MITHOEFER: I didn’t have any psychedelic training in my residency, but during that time Stanislav and Christina Grof trained me in Holotropic Breathwork, a meditative practice that uses breathing and music to activate natural inner healing and shift consciousness. It introduced me to the healing potential of nonordinary states of consciousness.

RH: The focus was on altered states of conscious, not necessarily with medication intervention?

MITHOEFER: Yes. In fact, my wife and I used this method of breathwork for 10 years with people before we started working on the first MDMA protocol in 2000.

RH: What tipped you off that MDMA might be a worthwhile treatment approach?

MITHOEFER: Several thousand psychiatrists and psychologists and other therapists were using MDMA in conjunction with therapy in the late ’70s, until it became illegal in 1985. I was aware of the controlled research and case reports from that time. I’d met with some of the psychiatrists who’d used it back then. Also, my wife and I had experienced it a few times ourselves in therapy, back when it was legal.

We knew it could be helpful in alleviating people’s suffering, and saw how it could help them communicate with less defensiveness and more openness. I was treating a lot of people with PTSD, and we wanted to study its usefulness as a catalyst to psychotherapy. So unlike most drug studies, we’re not just looking at the effect of the drug: it’s the experience in the therapy that we think is such an important part of the healing that MDMA can catalyze.

RH: Is MDMA the same thing as Ecstasy and Molly?

MITHOEFER: Ecstasy and Molly are supposed to be MDMA, but they’re often not. I read one report from the Drug Enforcement Agency a year or so ago that said something like less than 20 percent of the Molly and Ecstasy confiscated on the street had any MDMA in it at all.

RH: Why is MDMA so helpful with communication?

MITHOEFER: Well, we know it causes a release of serotonin as well as other neurotransmitters, like dopamine and norepinephrine. It also causes increased levels of various hormones, including oxytocin, which is known to increase affiliation in animal models, and helps humans experience others in a less negative way. It makes sense then that MDMA could make it easier to communicate if people weren’t as sensitive to interpreting someone else’s expression as being threatening.

RH: You’re saying the impact on the neurotransmitters can kind of smooth out communication and make things seem less fearful and threatening?

MITHOEFER: That’s right. We also know that MDMA decreases activity in the amygdala. That’s the fear center, and it increases activity in the prefrontal cortex, which is the higher processing center. In people with PTSD, there’s an increase in activity in the amygdala and decreased activity in the prefrontal cortex. MDMA has the opposite effect.

RH: So it allows people with PTSD to process trauma without the overwhelming emotional response?

MITHOEFER: Yes. There’s also a concept in psychotherapy called the optimal arousal zone—the space between hypo- and hyper-arousal where the brain is alert but not threatened. It seems that MDMA gives people a period of time in a more optimal arousal zone, with less likelihood of being overwhelmed by fear. They’re also not dissociated or cut off from their emotions. They have a sense of connecting emotionally with what they’re talking about, but without being overwhelmed by the emotion.

RH: Wow, that sounds pretty ideal: decreased fear, a relaxed amygdala, and prefrontal cortex firing. Why wouldn’t I want to be in that state of mind all the time? What’s the downside?

MITHOEFER: This is not a daily drug at all. We give it only at three different times, a month apart. People usually feel physically tired afterward, as it takes a bit of a toll on the body. Most people need a day or so to recuperate and get their energy back. It’s not the kind of thing you’d want to take all the time.

RH: What does the treatment look like?

MITHOEFER: First there’s careful medical, psychiatric, and psychological screening, which is done by outside psychologists. An independent rater does the measures; the clinician administered PTSD scale (CAPS) is our primary outcome measure. There’s another outside physician who does some medical screening that involves lab work and an EKG to rule out people who have serious medical problems, especially cardiovascular disease, because MDMA does increase pulse and blood pressure. Then we have three preparatory therapy sessions to get to know people and prepare them for what the focus of the sessions will be. The sessions themselves last for eight hours. People arrive at 9:30 a.m., we speak to them a little bit first, and then we give them the MDMA or a placebo.

RH: It is a research study after all.

MITHOEFER: Yes. Our trials are all double-blind. And they all involve people who haven’t responded to prior treatment for PTSD. During that eight hours, there are always two therapists present—male and female. In our studies, it’s myself and my wife. The therapists spend the whole day with a person, and we encourage alternating periods of inner focus, with periods of talking to the therapists when it feels right.

After we give people MDMA, we’ll encourage them to focus inward. Often they use eye shades and headphones with music, if they’re comfortable with those things. They spend time just focusing on their inner experience and then periodically coming out and talking to us. We check in with them every hour if they haven’t talked to us. Usually it ends up being about half the time talking to the therapist, and half the time focusing inward, in alternating periods. And we think it’s the person’s own inner healing intelligence that guides the process. So it’s quite a nondirective approach.

If people are stuck, the therapists respond to what’s coming up. I’m trained in Richard Schwartz’s Internal Family Systems (IFS) approach, so we may use elements of that. In fact, I did a substudy that showed that in a very high percentage of people, parts work comes up spontaneously, without having it introduced by the therapist. But generally, we try to see what each individual’s process is and then support that.

RH: Are you trying to nudge the person into certain therapeutic directions?

MITHOEFER: We never say, “Now it’s time to talk about your trauma.” At some point, people just start talking about their trauma. Sometimes they spontaneously talk about psychodynamic issues, and other times they recognize cognitive distortions and do spontaneous cognitive-behavioral work. Sometimes it’s parts work. We support whatever is coming up for that person.

RH: How do you conclude the eight-hour session?

MITHOEFER: We focus on wrapping up and making sure people are in an okay place. We don’t necessarily summarize, because quite often people feel like they just want to be quiet and let the process continue to percolate. But they don’t go home: they stay in the clinic overnight with a night attendant. That’s so they can have that time to let the process continue to unfold.

By 5:30 p.m., when the night attendant arrives, most of the MDMA effect has worn off, but people are still very connected to their experiences, so it’s kind of nice that they don’t have to go home and talk to a lot of people. They can be pretty quiet. They rest. And the therapists come back and meet with them the next morning for an hour and a half before they go home.

RH: Since it’s an illegal or controlled substance, how can you conduct the research?

MITHOEFER: There are extra steps to doing research with a schedule-I drug—which means we not only need FDA and IRB approval, but DEA approval as well. It’s quite a major process to get all of the approvals, but it can be done.

RH: If it becomes fully approved, this will be something that’s administered only by MDs, people who can already prescribe psychoactive drugs?

MITHOEFER: Any physician who can prescribe controlled substances will be able to prescribe the MDMA. But they won’t have to be the only ones doing the therapy. We’re talking to the FDA about this. What we recommend is to have it be limited to licensed MDMA clinics.

At one time, any physician could form a methadone clinic and get a license. So we think it’s going to be like that: a place where they’re set up to do it, with people who have the proper training to facilitate. It could be mostly nonphysician therapists, with a physician who’s responsible for the MDMA administration. We’re predicting approval, possibly by 2021.

RH: Have you started training therapists?

MITHOEFER: We have an organized training program with an online component and then two in-person trainings: one for six days and the other for five. A lot of that is watching and discussing videos of sessions, with some self-study in between, followed by a period of supervision and feedback. We’ve trained more than a hundred therapists. We’re going to need a lot more, so we’re always happy if people register their interest for the future trainings.

RH: What’s the most important thing for general therapists to know about MDMA treatment?

MITHOEFER: Part of the challenge is educating people about this rather strange treatment. Once people are informed about it, and see the outcomes, it actually makes a lot of sense.


This blog is excerpted from "The New Frontier in Trauma Treatment?" by Ryan Howes. The full version is available in the September/October 2017 issue, The Future of Couplehood: Esther Perel is Expanding the Conversation.

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Topic: Trauma

Tags: ryan howes | 2017 | breathing exercises | clinical psychopharmacology | drug treatment | drugs | Ecstacy | illegal drugs | MDMA | medication | neuroscience | neurotransmitters | psychiatric treatment | psychopharmacological | serotonin | street drug | therapeutic breathing

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1 Comment

Saturday, June 30, 2018 9:35:03 PM | posted by Harvey Hyman
This research is brilliant. I have been studying techniques such as brainspotting, EMDR, and IFS that purport to calm the client and put her in the window of tolerance between under activation (dissociation) and over activation (fight-flight) so the client's brain can process implicit trauma memories and achieve healthy neural integration. Brainspotting and EMDR use bilateral brain stimulation and the collaborative locating of a spot in the client's visual field that releases stored memories from trauma capsules in the brain. In IFS the therapist guide the client to find, focus on, and dialogue with her internal psychic parts. All 3 therapies must contend with client fear, apprehension, and anxiety over re-experiencing trauma. Brainspotters and EMDR therapists use "resourcing." Here Dr. Mithoefer has discovered how to use a drug to overcome fear, apprehension, and anxiety; to render the client non-defensive, open, and receptive; to switch on the client's loving and compassionate feelings; and to activate the PFC to sort through old distorted beliefs that cause shame, depression, anger, rage, etc. I love it. Once the drug has been cleared by the FDA for use in treating PTSD I want to get trained and use it for that purpose.