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2005 September/October (2)

Tuesday, 30 December 2008 10:46

Visionary or Voodoo?

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Visionary or Voodoo?

Daniel Amen's Crusade Has Some Neuroscientists Up in Arms

by Mary Sykes Wylie

Psychiatrist Daniel Amen is a trim, elfin figure with a puckish smile and the staccato delivery of a stand-up comic. The winner of a Distinguished Fellow Award from the American Psychiatric Association, a clinical professor of psychiatry and human behavior at the University of California, Irvine School of Medicine, the author of 20 books and as many peer-reviewed papers, and a hugely popular public lecturer and workshop leader, he sounds, somewhat paradoxically given his own sum, a bit like a wiseacre underdog impudently challenging a reactionary establishment. He cheerfully rails against the self-satisfied stuffed shirts from the worlds of academic psychiatry who, in defiance of reason and good sense, don't accept his view that a brain-imaging method called SPECT is an invaluable tool for understanding and treating psychiatric disorders.

"I just don't get it. Why are we the only medical specialists who never look at the organ we treat?" he asks, his voice rising in exasperation before a jam-packed audience of 500 therapists drawn to a full-day workshop on his work. "Why is it controversial to get more information on people who suffer? The images are really easy to understand. What's the problem with having more data?"

And then the "piece de resistance". We're always being told that the brain is so terrifyingly, irreducibly complex that nobody except Nobel-caliber neuroscientists could ever begin to understand how it works. But Amen says, in effect, that it really isn't that hard for anybody--with a little training--to get a good sense of what all those brain modules are actually up to. "The images are really easy to understand--you don't need to make it any harder than it is," he says, as if explaining a new recipe to an insecure cooking student. "All SPECT does is measure three things--areas of the brain that work well, areas that are underactive, and areas that work too hard. Then you just gear the treatments to rebalance these areas."

So why not just take a look? What's the harm? His case is helped by the elegant, crisply articulated, brain images he shows that, in concert with his simple explanations, seem to luminously reveal what's actually going on upstairs.

Amen flashes two computer-reconstructed, three-dimensional, exquisitely tinted color scans, each of a different brain. One, a "healthy" brain, is a smooth ovoid shape, with some softly modulated rises and depressions; if it were a landscape, it would be a gently rolling pastoral scene. The other brain looks an awful mess. With its deep fissures, crevices, and "holes"--areas of severely low activity--it looks as if uneven chunks of it have been eaten away by a voracious rodent. This latter brain, Amen dramatically announces, is the brain of Kip Kinkel, the 15-year-old boy from Oregon who, in 1998, shot to death his mother and father and then drove to his high school, where he shot 24 more people, killing two.

Kinkel, Amen explains, had been seeing a psychotherapist and taking both Ritalin and Prozac, which only made him worse--more volatile and unreachable. His demoralized parents had taken him off his meds, after which he went on his murderous spree. "If a scan had been done on him before the killings, it would have shown an extraordinarily abnormal brain," says Amen. On the SPECT scan, he tells the audience, Kinkel's prefrontal lobe--associated with impulse control, judgment, and planning--exhibits extremely low activity. At the same time, his temporal lobe, controlling such functions as temper and mood stability, also showed abnormal patterns of blood flow, which can make a person more prone to aggression, emotional volatility, and violent suicidal and homicidal thoughts.

"If his therapists had actually seen his brain, they could have put him on mood stabilizers, and the odds are they'd have diminished his violent thinking dramatically." Amen pauses to let this sink in. "But because the current 'state of the art' in psychiatry is not to look at the brain, his doctors were simply throwing darts in the dark. Today you can try to kill yourself or kill other people, and nobody will look at your brain. But if your brain's not right, you won't be right."

Amen has a vast fund of salvation stories about people misdiagnosed and mismedicated, often for years, whose real problems are only finally revealed through the combination of intense clinical detective work--the kind any good therapist would do--and the nuclear magic of a SPECT camera, which, literally, casts light into the hidden recesses of the brain. "Giving a diagnosis of 'major depression' or 'ADD,' is like giving a diagnosis of 'chest pain,' or 'belly pain,'" says Amen with some asperity. "These are symptoms with many, many possible causes. And one treatment will not fit every person with similar symptoms. We need to start looking at the brain, to begin seeing the underlying physiology of what's going on. Scans aren't the answer, but they're certainly part of the answer. A psychiatric profession that doesn't look at the brain is archaic, dated, and stupid."

Amen now has the audience in the palm of his hand, laughing at his jokes, moved by his stories of troubled little kids whose lives were either saved or ruined, depending upon whether their underlying brain problems were discovered and treated. He seems to be as much on a personal crusade as a professional quest. But, periodically, a note of unabashed salesmanship and self-promotion intrudes--the repeated references to his "cool" books and their worldwide distribution; his bestseller, Change Your Brain, Change Your Life ; his column for Men's Health ; his media appearances on The Today Show, The Leeza Show, CNN ; his recent gig at the National Security Agency. For some in the audience, it's enough to induce emotional whiplash: are we hearing from a fearless pioneer dedicated to transforming the mental health field or a salesman whose most important product is himself?

To be sure, Amen has acquired a small, but growing, crowd of supporters and colleagues in psychiatry, psychology, and nuclear medicine--he says more than 1,000 professionals refer to him--who consider him a trailblazer and believe SPECT scans will revolutionize the practice of psychotherapy. "I think he's a real pioneer, making an enormous contribution to the field of psychiatry and helping to change the paradigm of how people think about the brain and psychiatric symptoms," says Joseph Wu, professor of psychiatry and clinical director of the brain imaging center at the University of California, Irvine. "Daniel Amen introduced me to a whole new universe of subcortical brain structures that we in nuclear medicine had only looked at casually before. He helped me realize that SPECT can be very useful for evaluating complex, difficult cases in which comorbidities are present," notes Dan Pavel, professor of radiology and nuclear medicine at the University of Illinois. "I came away from Amen's clinic convinced there is a place for SPECT in clinical psychiatry," writes AD/HD expert Edward M. Hallowell, coauthor with John J. Ratey of the bestselling Delivered from Distraction: Getting the Most Out of Life with Attention Deficit Disorder. "It is obviously helpful to be able to look at the brain before you try to treat it. Perhaps SPECT will prove to be the most practical way for psychiatrists to do that."

But utter the name Daniel Amen to some of the leading members of the psychiatry and neuroscience research community and the reaction ranges from dismissal to derision and denunciation. "He's made a mountain of money doing scans [a two-scan evaluation at one of Amen's clinics costs $3,250, which also includes, a history, physician evaluation, and follow-up visit], but never, to my knowledge, published any data, or provided one shred of evidence that an independent investigator would be able to reproduce," says George Bush, psychiatry professor at Harvard Medical School and psychiatric neuroimaging researcher at the Martinos Center for Biomedical Imaging. "Amen is extremely successful, has many franchises and is a wickedly good salesman, but what he's doing isn't supported by scientific evidence. Where's his data? What does he know that all the other practitioners and researchers don't know?" asks Helen Mayberg, psychiatry and neurology professor and brain-imaging researcher at Emory University. In fact, so exercised is much of psychiatric officialdom by Amen's approach that, last January, the American Psychiatric Association's nine-member Council on Children, Adolescents and Their Families felt moved to issue an independent position paper opposing the use of SPECT in the clinical practice of child and adolescent psychiatry.

It seems strange that a person so disarming and apparently eager to please, who's clearly distressed by the uproar he's caused and seems like the last person who'd mount a Rambo challenge against entrenched power, would arouse such hostility. Or that his cause--the incorporation into psychotherapeutic and psychiatric practice of SPECT scans, a technology that's been around for decades--should be so contentious. So what is it about Daniel Amen and his mission to get therapists to use brain imaging, and SPECT in particular, as an aid to diagnosis and treatment that makes him such a lightning rod?

The Man Behind the Cause

Daniel Amen's personal and professional biography is a palimpsest of the odd and extraordinary, which may help explain why he's never found a home in the clubby atmosphere of the psychiatric and research establishments. His entrepreneurial success seems to particularly gall them--it adds insult to injury that he's not only doing something totally beyond the scientific pale, but making pots of money at it.

His talent for business seems almost foreordained by his background. His parents, the children of poor Lebanese immigrants, went to the West Coast during the 1940s. There, Amen pere began clerking in a relative's grocery store and then, embodying both the American dream and the ancient Phoenician talent for trade, worked his way up to become chairman of the board of Unified Grocers (a position he still holds), one of the largest wholesale grocery businesses in the country. Amen's family was large (five sisters, one brother), loving, but strict and Roman Catholic, headed by a tough, authoritarian paterfamilias. "I grew up with an extraordinarily successful father, who always expected the most from us," says Amen. "Our family honored work, and our lives were centered around work--I worked from the time I was 10. And nobody ever thought it was a bad thing to be successful."

Amen joined the Army at 18, partly because he had a low draft number, but also because his father told him not to. It was 1972, and the Vietnam War was in full swing, but Amen believed the recruiter who told him he'd be assigned as a vet's assistant. (He'd always loved animals and, as a teen, considered becoming a vet.) "I thought that the odds were good that nobody would be shooting at a vet's assistant." Instead, he ended up as a combat medic in Germany, where he got himself retrained as an X-ray technician, mainly so he could work in a nice, warm dispensary, rather than a chilly tent. But he became fascinated by X-ray technology and found that he loved studying the ghostly images of people's insides. "I looked at kidneys, lungs, skulls, thigh bones," he says now with remembered relish. "That's where the imaging story really begins."

Because of his religious background, Amen had seriously considered becoming a priest, but, as he says sardonically, "I couldn't stand the idea of being called 'Father Amen.'" He declined the priesthood, but certainly not religion. In Germany, he found himself drawn to the wholehearted, emotional expressiveness of Pentecostalism--shouting, praying in tongues, healing ceremonies, and all--so different from the restrained solemnity of the Roman Catholic mass. He was sufficiently moved by his new religious tack that, when he returned home, he got off the plane dressed in a "Jesus loves you" T-shirt and carrying a Bible, much to the consternation of his blindsided mother. By this time, 1975, he knew he wanted to go to a small school, and a religious one, so he finished his college education at Vanguard University, a small Christian college. Then, in 1978, he became a member of the first class of a newly opened medical school (since closed) at Oral Roberts University.

The nexus between capitalism and religion appears to have shaped Amen's life. In Healing the Hardware of the Soul, his book about the connection between a healthy brain and the capacity for morality, conscience, and faith, Amen writes that he felt "led by God to pursue this [SPECT] work." These days, he uses his training and skills as a kind of reverse mission to churches, in an effort to persuade Christians and Jews that much "sinful" behavior may be due to brain problems, rather than evil motives. Some of his critics haven't looked kindly on this sense of religious mission. "He's a true believer, and evangelical medicine is scary," says Mayberg.

After medical school, Amen took a residency in psychiatry at Walter Reed Army Medical Center. In 1987, the Army sent him to Fort Irwin, California, as the chief psychiatrist--the only psychiatrist in the middle of the desert for thousands of soldiers and their families--a population rife with drug abuse, depression, anxiety, domestic violence, psychosomatic ailments, and stress. This new gig would have been a daunting job for any psychiatrist, let alone a young, newly minted, and relatively untried one.

Serendipitously, in the old World War II building that housed his office, he found an antiquated biofeedback machine (an instrument that measures physiological responses, via electrodes or sensors attached to various parts of the body) left by his predecessor. He found that, even as a novice, he could use the machine to train people to warm their own hands by using their imaginations--thinking about burying their hands in hot sand, for example. He could also use it to help them reduce their anxiety or relieve their migraine headaches, while gaining a sense of self-control and personal mastery. Enthusiastic about his new toy, Amen convinced his dubious commander to pay $30,000 for an up-to-date model and send him for 10 days' training in biofeedback.

The biofeedback training program in San Francisco was, Amen remembers, a revelation: "The best, most exciting, training I'd ever had. I was just stunned by what I learned." It was the first major introduction he'd yet had to the powerful interaction of brain, body, and mind, and he was hooked. He discovered that people could learn how to control their own autonomic nervous system--relax their muscles, calm their breathing, reduce their sweat-gland activity, lower their blood pressure and heart rate--to relieve both physical tension and mental anxiety. Moreover, through neurofeedback (a form of biofeedback in which electrodes are attached to the scalp), they could learn to change their own brain-wave patterns, and thus their mental states. "I was so excited to have this cool new technology that I went back to Fort Erwin and started using it on everybody."

Amen was particularly anxious to try out this new brain-mind technique on kids with AD/HD. "Standard psychotherapy, as I'd been trained to do with AD/HD kids, made me crazy--they just never got any better," he recalls. Medications helped, but not nearly often enough, and there was no way to predict whether or not they would work. So Amen began using neurofeedback with his AD/HD patients to encourage more normal brain waves and reduce their symptoms. While not exactly the fast-track cure he'd have liked (it could take from one to two years to produce significant improvement), neurofeedback did work encouragingly well, with the side benefit of helping many kids avoid or lessen medications. In 1989, when he opened his private practice in northern California, he equipped it with his own biofeedback equipment.

Amen's clinic was an immediate success, no doubt partly because of the workaholic habits, business acumen, and marketing skills he says he inherited from his father; but also because he was the only child psychiatrist for 300,000 people in the county. During this period, he worked six- and seven-day weeks, building up his practice, directing the dual-diagnosis unit of a local hospital, lecturing in the local community, and writing a news column (he'd already published two self-help books on getting ahead in school and in work).

In March 1991, Amen attended a lecture on SPECT imaging at the hospital where he worked. If learning about neurofeedback had been a revelation to him, seeing SPECT scans was an epiphany. SPECT is the acronym for single photon emission computerized tomography, a nuclear-medicine imaging technique that measures an organ's blood flow or activity level--its function . An MRI, by contrast, looks at brain structure or anatomy, just as an ordinary X-ray does (but provides far more detailed images). A patient being SPECT-scanned is injected with a "radiopharmaceutical" and then lies on a table for about 15 minutes while a multiheaded camera rotates around his or her head picking up gamma rays (which are like pulses of light) from the radioactive material taken up by the brain cells. The data obtained by the camera are processed by a supercomputer to produce a series of two-dimensional cross sections of the brain. Different activity levels--relative blood flow--show up as shades of different colors or gray tones, depending on the color scale of the software program chosen by the imager.

These cross sections are then reconstructed into three-dimensional images. Notwithstanding Amen's suggestion that brain scans "aren't that hard to read," it's definitely not a simple process, requiring real skill and judgment to do well. To a lay viewer, the cross sections that first come out of the computer look like a meaningless kaleidoscope of colors and patterns. It takes an expert in reading, understanding, and manipulating the scans to tweak them into an accurate but elegant form--the dramatic, 3-D pictures of the kind Amen shows his audiences.

The Society for Nuclear Imaging officially recognizes only four common indicators for the clinical use of SPECT: to detect and evaluate strokes, brain trauma, and suspected dementia (a recent article says that brain scans like SPECT can predict Alzheimer's disease nine years before people have symptoms), or to locate focal points of epileptic-seizure activity. But SPECT has been used in a huge and highly eclectic number of research studies on almost every conceivable psychiatric and neurological condition, as well as some nonpsychiatric studies, like measuring the impact of meditation and prayer on blood flow to different brain areas.

The lecturer at Amen's hospital, a local nuclear physician named Jack Paldi, showed brain images of patients with depression, dementia, schizophrenia, and head trauma, comparing them with normal brains. Using these amazing images, Paldi tried to demonstrate that one could actually see the differences between brains that worked well and those that didn't, see how medications changed the way brains functioned and where those changes occurred. In this rush of graphically astonishing images, Amen thought he could begin, finally, to understand why some of his patients just couldn't seem to benefit from therapy or get their lives in order, no matter how hard they tried. It wasn't psychological resistance or personality type or deep-seated unconscious motives that kept them from getting better: it was simply that the software of their brains wasn't up to speed!

"I was absolutely blown away," remembers Amen, who took up Paldi's offer to do no-cost SPECTs on interested physicians and, six months later, got one himself. Shortly after the lecture, however, he ordered 10 scans on particularly difficult patients, which, according to Amen, resulted in "literally miraculous changes" in five of them. One patient was a 12-year-old boy with a nasty temper, a history of aggression, and school failure, who'd been hospitalized three times, prescribed assorted drugs (including Ritalin, which made him hallucinate), and treated with two years of psychoanalytic therapy. The scan showed low temporal-lobe function (associated, as in Kip Kinkel's case, with anger, violence, and mood swings), as well as frontal-lobe problems (which kept him from being able to concentrate in school). Amen placed him on mood stabilizers and a different stimulant, and voila! Within three weeks, he became milder tempered, began making friends, and, says Amen, "turned into the sweetest boy you'd ever want to meet." His school performance improved dramatically as well.

Another woman had been diagnosed with Alzheimer's after she'd nearly burned down her own home and lost her driver's license. Amen scanned her and found no signs of the characteristic abnormalities associated with dementia. But he did see that her deep limbic structures were "on fire" (a favorite bit of Amen-speak to describe brain areas of severe overactivity). This suggested depression, which can sometimes mimic Alzheimer's symptoms of memory loss, apathy, indifference, and disorientation. Amen prescribed Wellbutrin--an antidepressant and stimulant--and voila` again! Within weeks, she'd regained her memory, and her mood was much better. Within six months, she got her driver's license back.

"How many experiences does a psychiatrist have like these in a whole career?" Amen asks. "I had five of them in the space of a few weeks."

By Amen's lights, SPECT was not diagnosing new conditions. The scans didn't remotely correlate with DSM diagnostic categories, but they often revealed the inaccuracy of previous diagnoses and suggested functional anomalies that shed light on otherwise unexplained symptoms. Nor were his treatments miraculous, radical, or novel; they apparently just hit the target better than earlier interventions. In short order, he was a true believer in the modality. "I thought, 'How can I do psychiatry in good conscience without using scans when I don't really understand what is going on? How can I just continue to rely on guesswork when I have this tool at my disposal?'"

Between 1991 and 1995, he became something of a SPECTomaniac, reading everything he could find, attending meetings about SPECT, and ordering SPECT scans on hundreds of patients at the local hospital. He was asked to talk about SPECT at hospitals and at the University of Colorado medical school. He wrote a research paper comparing SPECT brain images of ADD children to those of normal children. He became an enthusiastic promoter of SPECT.

But there were signs of smoke from an impending firestorm almost from the beginning. In 1992, at a meeting of the American Psychiatric Association (APA), where he attended an all-day course on the use of SPECT in child psychiatry, he went to a lecture by National Institute of Mental Health child-psychiatry researcher Alan Zametkin. This would-be colleague used PET scans (a form of nuclear imaging with higher-quality resolution than SPECT, though more difficult and expensive to use) in a groundbreaking study of what ADD brains look like. Zametkin, says Amen, was one of his heroes, so he went up to him after the talk in the spirit of a fan approaching a star. "I told him that, partially based on his work, I was using SPECT in my own practice," remembers Amen.

But if he'd expected an avuncular smile of approval, he was mistaken. Zametkin angrily barked at Amen that these techniques were strictly for research and in no way intended for clinical use. In no uncertain terms, he told Amen, in effect, to cease and desist what he was doing.

"But why do you do these studies if you don't intend this technology to be used clinically?" Amen asked, baffled.

"I do them just to learn more; it's interesting basic science," Zametkin replied loftily.

This is an attitude foreign to Amen. "I really have no interest in science for science's sake," he admits. "I'm a clinician through and through--it's my reason for living. I get my juice from my practice, from relationships with patients, not from research."

Back home in California, the natives were also getting restless. A local pediatric neurologist, after calling three or four researchers around the country and hearing that SPECT wasn't ready for clinical prime-time, complained to hospital officials about Amen's heterodox behavior. "The neurologist told me that my reasons for ordering scans weren't empirically proven, and that I should quit doing them. He said, 'The brain is for neurologists, not psychiatrists,'" Amen recalls, even now incredulous. "I told him he was nuts." At a meeting of the hospital authorities, Amen was given permission to continue getting SPECT scans for his patients, but he was now required to have the medical director sign off on his requests.

In 1993, he was asked to help teach a brain-imaging course at the APA annual meeting, but when the program came out, a Dallas SPECT researcher wrote the APA program chairman demanding to know why such a controversial figure was included. The program committee chair sat in on the presentation and supported Amen's work, but many others were openly hostile to him, making a point of telling him he was a fraud and a mountebank and ought to be drummed out of the medical profession. It had gotten to be too much, so he decided to retreat from the public field, help his patients in the relative privacy of his clinical practice, and let other people do the research and fight the battles.

It's hard to imagine as restless and driven a figure as Amen ever really settling for a quiet, low-profile practice in suburban California, so he'd probably have taken up the gauntlet again sooner or later. But a crisis involving his 9-year-old nephew, Andrew, launched him back into the fray.

Amen's sister called him in tears one day early in 1995, telling him that her son--his nephew and godchild--had attacked a little girl on the baseball field for no reason. Over the preceding year, this friendly, active, outgoing little boy had become surly, angry, mean, and depressed, and had begun drawing pictures of himself shooting other children or hanging from a tree. Amen told his sister to bring the boy in the next day and, after a lengthy interview, personally took him to the hospital to be scanned. "When I looked at the image, I saw he had no left temporal lobe at all!" recalls Amen. This was, again, a part of the brain associated with violence, aggression, and suicidal and homicidal feelings. Andrew was almost immediately given an MRI scan, which showed a cyst about the size of a golf ball where his temporal lobe should have been.

But Amen couldn't find anybody willing to remove the cyst. Three pediatric neurologists--one at Harvard--told him that Andrew's behavior was probably not related to the cyst and that they wouldn't remove it until there were "real symptoms." Amen was beside himself. "Hearing this made me nearly psychotic, I was so angry." He remembers shouting, "What do you mean, 'real symptoms?' You don't think suicidal and homicidal thoughts and behaviors in a 9-year-old are real symptoms?" Real symptoms, the Harvard neurologist coolly informed him, meant seizures and speech problems. Period.

Finally, he located a pediatric neurosurgeon at UCLA who said he'd operated on three other children with the same problem--a temporal lobe cyst resulting in aggression. This doctor performed the operation on Andrew. When the boy finally woke up after the surgery, he smiled at his mother--the first smile from him she'd seen in more than a year. Shortly afterward, he became, once again, the youngster he'd been before his problems began.

This event changed Amen's life, he says. "From that moment on, I felt I could no longer be shy, or allow myself to be hurt by criticism, or fearful that people wouldn't like what I was doing. I just thought of all the kids who are in residential treatment facilities or end up in prison because they've done terrible things, and nobody ever even knows whether or not it's because they have something terribly wrong with their brains."

Now a newly energized Amen charged full-steam ahead. He completed the 1,000-hour training and supervision program to obtain the license in handling radioactive material that's necessary to do scans, bought SPECT equipment, and became, as far as he knows, the only psychiatrist in the world who had then incorporated brain imaging in his own practice. He once again took up the SPECT gospel and began spreading the word, and once again was met with virulent attacks.

In 1996, after Amen gave the State of the Art Lecture in Medicine at the Society of Development Pediatrics, a San Francisco pediatrician stood up and excoriated him for using brain imaging to justify giving drugs to children for AD/HD--in effect, accusing him of shilling for Big Pharma. Shortly after the meeting, he was anonymously reported to the California Medical Board for practicing outside the generally accepted standards of care. The state medical board began an investigation, which took a full year--of lawyers, interviews, questions, reviews of his articles, office visitations. "The worst year of my life," Amen calls it. Finally, after his work was sent to the departments of neurology and nuclear medicine at UCLA, he was exonerated and became an expert reviewer of psychiatry for the California Medical Board.

Amen and His Critics

Today, about eight years later, Amen has no doubt succeeded as a medical entrepreneur. He has two clinics in California, one in Washington State, and one in Reston, Virginia. By any measure, he's a huge success. Besides founding his clinics and cranking out books (another is on the way), he's produced a "Clinician's Toolbox" of brain-related materials for therapists, a brain-scan atlas, and assorted CDs and videos. He's given more than 100 presentations in the United States and abroad, written or been the subject of numerous articles in the popular press, appeared on scores of radio and television shows, testified at numerous trials, and developed a 12-week high school course on the brain to be piloted in 30 schools this fall. There are perhaps 15, mostly for-profit, psychiatrist-run clinics around the country that now use SPECT--a fair number of the proprietors trained by Amen himself. In addition, an indeterminate number of psychiatrists around the country quietly, but regularly, refer their own patients for brain scans.

Nevertheless, most of the research community and the psychiatric establishment remain deeply unimpressed. Indeed, there isn't anything about Amen or what he does that his critics do like. Following the back-and-forth between them and him is like watching a bunch of increasingly infuriated boxers all trying to knock down an inflatable punching doll--the harder they hit, the faster he bounces back. They argue that Amen isn't competent to use scans because he's not board certified in nuclear medicine, didn't train in radiology (his several hundred hours of imaging training don't count), and doesn't follow science-based methods of differential diagnosis (using appropriate tests to differentiate systematically between distinct diseases with similar symptoms). He counters that he has the proper licenses to do his studies, teaches SPECT at a major medical school, has written or cowritten chapters about SPECT in three professional textbooks, has produced nearly two dozen peer-reviewed papers, instructs nuclear-medicine doctors who come from far away to spend weeks at his clinic, has chaired workshops on SPECT at the APA annual meeting, and, finally, just a year ago, received a Distinguished Fellow Award from the APA. "I have more experience with SPECT than anybody else in the world, and there are mountains of scientific literature backing up my clinical work--1,500 such studies are on my website alone."

They argue that he sits on a proprietary stash of 27,000 scans, like a miser sitting on a pile of gold bullion, and won't give researchers access to his data because he's afraid an independent look will undermine his claims. He contends that researchers are perfectly welcome at his clinic, to talk to his doctors, see how they interpret scans, and look at his database. But one leading researcher he invited out to see his scans hasn't followed through, and no one else has ever asked to see them.

They say, to quote Harvard's George Bush, that "he's unethically subjecting people, including children, to potentially dangerous ionizing medication in a diagnostic test of no proven benefit." He cites Michael Devous, a leading nuclear-medicine expert, who writes that "there are no data that have ever demonstrated any harm to humans by radiation exposure at diagnostic imaging levels." The average radiation exposure for one SPECT scan, Amen points out, is similar to that of an abdominal X-ray, which is routinely ordered for common childhood medical conditions, including constipation.

They say, repeatedly and maddeningly in Amen's view, that he claims to diagnose psychiatric illnesses from the scans. He just as repeatedly insists that he never uses SPECT to "diagnose" anything, but looks at the scan within the context of the person's life and after a full psychiatric evaluation to get more information that might shed light on puzzling, difficult, or anomalous symptoms. "I've never said the image is 'the answer.' We use it when we don't know what's going on, when we think it might supply a piece of the puzzle--it's like radar that helps us better target the problem. The alternative to doing scans is blindly putting kids on meds or multiple meds without looking at their brains either before or afterward."

Finally, and most damagingly, they say that what Amen is doing is totally unsupported by the facts--that he hasn't remotely demonstrated the scientific validity or reliability of using scans as he does. They argue that it isn't yet possible to identify subtle distinctions in single subjects that reliably correlate with specific symptoms. "When a radiologist looks at a chest X-ray, he recognizes pneumonia, or an enlarged heart or liquid at the base of the lungs that correlate with disease because he's compared these abnormal scans to thousands of normals and other abnormals," says neuroscientist Bush. "Maybe in 50 years, when someone comes in looking as if he or she has a certain syndrome, we'll be able to refer them to a radiologist who'd be able to interpret that individual scan. But we're not yet, as a field, in a position to distinguish one brain scan from another. Right now, you can look at any individual scan and what you'll find is color blobs across a screen. What separates science from nonscience is the ability to pick out quantitative, statistically reliable, patterns [in those blobs] based on large numbers of scans--set certain criteria for a disorder, show it in 50 cases compared with 50 normals, for example. Amen isn't doing that. Essentially, all he's doing is 'blobology.'"

To this, Amen responds that factoring in the individual variability in each brain, rather than drawing general, statistical inferences from a large base of cases, is a strength of his method, not a weakness. Researchers look for signature features in a scan that will reliably correlate with specific DSM categories, which do not reflect the complexity and heterogeneity of psychiatric disorders as they're experienced by real people, Amen argues. " DSM diagnoses are artificially derived from symptom clusters," he says. "But they don't explain why people are having these symptoms--why one person's depression or anxiety or AD/HD may be entirely different from the same formal diagnosis in somebody else. Only by looking at each person's individual scan can you get some insight into the underlying physiological pattern in the brain, so we can target treatment specifically to what that person needs."

In addition, he says, researchers study "pure" cases--people with one supposed diagnosis without the confounding variables of comorbid conditions (i.e., drug addiction along with their depression, AD/HD symptoms along with their anxiety). This approach simply doesn't reflect the complexity, variability, and individuality of real people and real patients.

Finally, researchers compare people with a DSM diagnosis to presumed "normals," but Amen doubts that there's such an entity as a "normal" brain. Recruiting people for a database of normals, his office screened 1,500 people and found only 72, who met the criteria for "normal"--no signs of head injury, no history of substance abuse, no psychiatric illness, and no first-degree relative with a psychiatric illness. "'Normal' is a myth," he says flatly.

Whatever the specifics of his critics' objections to Amen's work, it's hard not to suspect that underlying the intensity of their response is their objection to Amen himself--his persona, his style, his modus operandi. Most scientists lead comparatively monastic, inconspicuous lives (though not necessarily impecunious--many act as paid consultants to pharmaceutical and medical-device companies). Even those few who achieve eminence do so largely within the circumscribed universe of their peers. How many people can name a recent Nobel laureate in any scientific field? They have their own worldview, and what they consider Amen's heavy-handed promotion of high-tech gimmickry is as far from it as earth is from Pluto.

"The nature of science is agnosticism," says Helen Mayberg in a passionate defense of the way researchers do things. "Our job is to ask questions, measure data, continue doing the research until we find out what's real, what isn't. I've devoted my entire professional life to using imagery to understand depression, and the more progress I make, the more complicated it gets. As a clinical neurologist, I see patients die all the time. I don't have to have anybody tell me how much people suffer. But no matter how much, as a doctor, I want some idea for a promising new treatment to be true, as a scientist, I have to remain an agnostic. We all know the system isn't as good as it should be, but it's the best we've got. We get accused of living in ivory towers, but we do what researchers do--we can't leapfrog over the process."

For researchers like Mayberg, Amen is anathema--a leap-frogger to the nth degree. His disregard for professional politesse can make even his friends and defenders cringe. Jerry Rodos, a psychiatrist in the Chicago area, who regularly refers difficult patients for scans, remembers taking a younger colleague to hear him lecture. "We walked into the conference room, my friend took one look at the Amen concession--tapes and books and CDs, advertisements for his clinics, posters, etc.--and was completely turned off before he even sat down. I think Dan has done a lot of neat work, and what he is saying is very valuable, but he's not a traditionalist and hasn't spent a lot of effort trying to get refereed journals to review his material. If you have something important to say, you submit it to peer-reviewed journals, rather than just run off and start four clinics and write popular books about it. Dan Amen is a big promoter of Dan Amen, and that offends many of his colleagues."

Partly in response to critiques like this, even from allies, Amen has hired a statistician-researcher and is preparing several studies, including one on predicting treatment response in AD/HD patients based on their different scan subtypes. But Amen doesn't believe his opponents will come to like him anytime soon, no matter what kind of studies he publishes. "A friend of mine told me I was like somebody under an old Romanian curse--doomed to know something that's true, but nobody believes him," he says gloomily.

The Client's Experience

Meanwhile, anathema or not, Amen's clinics do 400 to 500 scans a month, and, according to follow-up questionnaires given one month and six months after treatment, 85 percent of this patients think they received "significant benefit" from the process. According to therapy researcher Jay Lebow, however, this isn't unusually high--about 90 percent of psychotherapy users report being satisfied with their treatment, which can simply mean they liked the therapist and felt understood and cared for.

At least some of Amen's patients, however, clearly feel that the experience transformed them, even saved their lives. Whole families get scanned, and then refer their friends and acquaintances and fellow church-members. Some of Amen's most convinced champions are evangelical Christians, who believe that Amen is doing God's work and want to help him do it. Linda and Gaylen Bronson, a California couple who are committed Christians, were so delighted with Amen's treatment of their family that they started the Recovery Assistants Foundation, a tax-exempt, charitable organization that helps people who couldn't otherwise afford it to get and pay for SPECT scans, therapy, and medications.

To get some idea of how the Amen phenomena can build on itself, consider the Woodmansees--Jack, a retired general and businessman, and his wife Patty--who live in a suburb of Dallas. The Woodmansees heard about Amen a decade ago from a friend who felt the SPECT scan and his treatment had dramatically improved her life. Because the Woodmansees had a grandson diagnosed with AD/HD, who was doing very poorly on Ritalin, they sent for an Amen video about AD/HD. Watching it as a family, their adult son (the father of the AD/HD child) came to the conclusion that he probably had AD/HD, too. The senior Woodmansees made appointments for the son and grandson to get scanned, and then decided to take their granddaughter, who had behavioral problems. Eventually, three different branches of the family trooped out to California to be scanned.

Soon they were all talking about the temporal lobes, cingulate gyrus, prefrontal cortex and noting the interesting family resemblances in their brain-perfusion patterns. They also became advocates for Amen, sending along friends, neighbors, and members of their congregation, and even financing scans for people who couldn't afford them. They brought Amen to Dallas to give lectures, and have been trying to convince him to open a clinic there.

Two years ago, Richard and Sarah Mitchell took their 10-year-old daughter, Terry, in for a scan. Always a difficult child, Terry was now throwing herself on the floor in explosive temper tantrums, harassing her siblings, causing classroom disruptions, and failing in school. Diagnosed with AD/HD and oppositional defiant disorder, she'd been prescribed a stimulant, which she vociferously fought taking, and which only made her worse. After the scan, Amen prescribed an antidepressant, a mood stabilizer, and a handful of supplements. He also recommended several therapists. But not one of the three therapists worked out, and the drugs didn't help much, either.

So Amen shifted course. He took Terry off meds, cranked up the supplements, including large doses of over-the-counter omega-3 fatty acids, GABA, and other amino acids (believed to reduce anxiety), recommended a high-protein diet, and helped her parents learn some techniques for handling their daughter better. Now, about two years later, Terry still tends to be bossy and overbearing, has a hard time picking up on social cues, and is emotionally immature. But she's much better than she was--her grades are now high Bs, she likes school, and her mood has generally improved. "She isn't raging anywhere near as much," her mother reports, and she clearly feels more at peace with herself.

Terry's case points to a paradoxical and perhaps misunderstood aspect of Amen's approach. However radical the use of SPECT may seem, his treatment is unconventional only in that it's far more heterogeneous and informed by alternative-healing methods than the Johnny-one-note pharmaceutical orientation of most psychiatrists. While not shy about prescribing medications, often in twos and threes, he also recommends nutritional and herbal supplements, cognitive therapy, EMDR, biofeedback, parenting-skills training, diet, exercise, meditation, and abstinence from alcohol.

How does treatment with Amen compare with what another psychiatrist might recommend? Might not Terry, for example, have done just as well if she'd found a reasonably creative and open-minded therapist willing to try a variety of different approaches and hang in with the family for as long as it took? Of course. Did the SPECT scan speed up the process? Possibly. Does Terry's family believe that scans are magical keys to the kingdom of the inner brain and that Amen is the sorcerer who, essentially, saved their child? Completely. "Without Dr. Amen, she'd probably be in some military school now," says Terry's mother. "I feel blessed to have met him." Among the Amenophiles, this attitude isn't unusual.

For all that people say about what most mattered to them about their experience at one of Amen's clinics, it would be a mistake to underestimate the weight of the old saw that a picture is worth a thousand words. People believe they're seeing an actual picture of something empirically real, fundamentally true, and undeniably revealing about themselves. This apparently incontrovertible glimpse of reality can be unwelcome, even shocking, but it has to be taken seriously. Before the scan, Terry Mitchell had furiously refused to take medications, and felt her parents were disciplining her unfairly. When her scan was shown to her and explained, she looked at it quietly and somberly for a long time, and said, "I guess I really do need medications." It's easy to believe Amen when he talks about the power of these scans to convince even adolescents that the drugs they ingest really are hurting their brains--there's the evidence.

Critics might argue that this troubled child has been conscripted into a possibly false sense of her personal pathology by a misused and misleading test. But, paradoxically, scans that show something amiss can be oddly reassuring. "Do you know what people's biggest worry is about seeing their scan?" Amen asks. "That the scan will show nothing ; that it'll look normal, which means that they're suffering because they're weak or bad." After her scan, Terry felt relieved, her mother said, because the scan explained why she was having so much trouble and removed her sense of self-blame for not acting like a "normal" girl.

Brain and Soul

This peculiar, but almost universal, sleight of thought--"it's not me, it's my brain "--helps explain Amen's appeal and, for that matter, the appeal of all "biological psychiatry." Whether or not we're religious, spiritual seekers, or hard-nosed materialists, we feel intuitively that our real selves, our souls, if you will, aren't the same as the soft "hardware" of the brain. And unlike many drive-thru drug dispensers, as psychiatrists have too often become, Amen actually seems to care about the soul, perhaps even in some way believes he's doing his part to save souls, or at least free them from the malign influence of a sick brain. And clearly, Amen and his staff do everything they can to make the people who come to them feel like real people with basically whole souls, whatever is wrong with their neurophysiology.

Recently, Ted, a nonprofit administrator who'd seen Amen at the Networker Symposium, decided to get his own brain scanned in Amen's clinic in Reston, Virginia, which is directed by psychiatrist Charles Parker. Now in his mid-fifties, Ted says he's been depressed since his late thirties. He describes his emotional state not as sadness so much as apathy, lack of energy, zest, and motivation. "Nothing's wrong in my life. In fact, I think I have a great life. I just don't enjoy it very much," he says. He also has a hard time concentrating and, while he used to read a lot, now just zones out in front of the TV. He was in therapy many years ago, though not since becoming depressed, and has tried a number of medications--Prozac, Wellbutrin, Cymbalta, Paxil--and acupuncture, all to no avail.

Ted loved his whole experience at the Amen clinic. The staff seemed entirely made up of young, attractive, extraordinarily pleasant women with big smiles who, Ted was intrigued to see, all wore very high heels. "It was a little like the Stepford Wives, only they seemed genuinely nice." He filled out a 15-page questionnaire, went through a lengthy interview with the "historian," and then underwent a concentration scan. Two days later, he went in for his resting scan, and a day or two after that, Dr. Parker reviewed the scans with him.

Ted found Dr. Parker to be the nicest person of an amazingly nice staff, scoring about 110 on a 100-point friendliness scale. "The psychiatrist I go to for my meds checks is a nice enough guy, I guess, but he's like an iceberg compared to Dr. Parker, whom I liked much better. He really seemed to want to spend as much time with me as I needed."

As for the scans and what emerged from them, things get a little murky. The report was long, complicated, and somewhat confusing to Ted, who said that, as he listened, "after five minutes or so, I kind of glazed over." The scans showed less than normal perfusion in areas of the prefrontal cortex, temporal lobes, and parietal lobes; increased, or excessive, perfusion in the basal ganglia and limbic system; and "scalloping," or dehydration, on the outer surface. Altogether, all of this signifies . . . well, a lot of possibilities--including, but not limited to, short attention span, low motivation, memory problems, abnormal perception, impulsivity, disorganization, distractibility, anxiety, irritability, depression, and mood cycles.

In this somewhat jumbled mass of findings, what fascinated Ted the most was the pronounced indentation in his left prefrontal cortex, consistent, said Parker, with past brain injury. Amen contends that many psychiatric conditions may result from undiagnosed, and even apparently mild, brain trauma without unconsciousness, and he makes it a practice to ask his patients at least five times if they've ever experienced head injuries. Ted was also interested to learn that several of the patterns picked up on in the scan are often seen in people with AD/HD.

The upshot of all this was that, according to Parker and Amen (who read the scan), Ted had been taking the wrong medication--Cymbalta only exaggerates symptoms of AD/HD and concentration difficulties. He was to begin taking Effexor right away, and Adderall a few weeks down the line. Besides this, he should begin exercising and take various supplements. Ted was given a list of books and referrals to holistically trained MDs specializing in nutrition and brain-injury recovery, neurofeedback experts, and brain-health websites. He was also told to make a follow-up appointment. For a technique that's supposed to provide the focus for well-targeted, specific clinical interventions, Ted's SPECT scan seems to have resulted in something of a hodgepodge of generic recommendations.

But Ted came away from his adventure feeling elated--less like somebody who's had a high-tech medical procedure with no very clear prognosis, and more like somebody who'd won the lottery and been given a new lease on life. "I thoroughly loved the whole thing. I'm very glad I did it. It was uplifting and made me feel so hopeful." And the scans? "They're interesting to look at--very pretty. It's neat to have somebody show you what your brain looks like. And then to be shown this big indentation that's not supposed to be there; well, it's concrete evidence that something really did happen to you. I do think I understand my own brain a little bit better."

Whatever the outcome for Ted's case, or for Amen's crusade overall, it seems inevitable that his work, or some variant of it, represents a glimpse into the future. With the development of revolutionary new technologies permitting a direct look inside the brain, people will be increasingly dissatisfied with the clinical guesswork and serial medication trials that constitute so much of psychiatry today.

Nor will psychotherapists, the workhorses of the mental health industry, be content to wait until the last peer-reviewed, double-blinded study demonstrating SPECT's empirical validity and reliability has been published before making use of these technologies in their own practices. They've never been willing to delay using what seemed useful to their patients until they've gotten the okay from the higher orders of scientific inquiry. EMDR and many forms of body-oriented trauma therapies, as well as a host of other therapeutic methods, are still considered fringe by research psychologists, but that isn't stopping therapists from using them. Whether one considers Amen a devil or a new messiah, his use of SPECT visionary or voodoo, it seems likely that time is on his side.

Mary Sykes Wylie, Ph.D., is a senior editor of the Psychotherapy Networker. Contact:

Tuesday, 30 December 2008 10:32

Alice in Neuroland

Written by Annika Land

Alice in Neuroland

Can Machines Teach Us to Be More Human?

by Katy Butler

It is a rainy morning in early March. I am in a hotel conference room near MIT in Cambridge, Massachusetts, running a dressmaker's tape measure through the reddish blonde locks of a mildly anxious physician named Marcia Lipski. At tables all around us, assorted psychotherapists, MDs, and speech pathologists are clustered in groups of three, with laptop computers, electrical wires, plastic tubes of unfamiliar goop, and white Styrofoam heads bought from a wig-supply house and pasted with orange stick-on dots denoting various parts of the brain. We are in the midst of a training presented by EEG Spectrum and accredited by the Biofeedback Certification Institute of America in the fundamentals of neurofeedback: a hybrid of biofeedback, old-fashioned counseling, and cutting-edge brain science. Attendance is restricted, on the whole, to health care professionals.

The clinicians around me are attempting to integrate their 20th-century therapeutic skills with 21st-century electroencephalography (EEG) and affective neuroscience. Those who once aspired to be sages, healers, and wise women will struggle over the next few days to make sense of hertzes, thalamocortical relays, frequency reward bands, and inhibitory postsynaptic potentials.

I feel like a student at a beauty school run by the Bride of Frankenstein.

Consulting my wig-head, I move my finger to a point on Marcia's scalp about two and a half inches above her right ear. In the spot below my finger, beneath a quarter-inch of bone, lies a cluster of 20,000 pyramidal neurons stacked three deep on the outer layer of her brain's sensorimotor strip, which governs body sensation and movement. Marcia's companion, Marvin DeVoe (a handyman by avocation and the only unlicensed trainee in the room besides me) squeezes a salty, gritty paste called Nu-Prep onto the spot I've indicated and scrubs.

I smear a chickpea-sized lump of clear, viscous wax onto an electrode--it looks like a tiny, gold cokespoon with a long, yellow, electrical wire attached--and press it onto the freshly cleaned spot on Marcia's scalp. Like a stethoscope pressed against a wall to eavesdrop on a party, this little spoon is capable of "hearing" faint electrical signals pulsing from neuron to neuron beneath the bone.

We clip earring-like electrodes to Marcia's ears, run a few electronic tests, and plug the electrode wires into a small amplifier leading to a laptop. Marvin hits a computer key. On the screen, four squiggly lines, like tracings from an earthquake-monitoring machine, dance grayly across a dark field. It's Marcia's EEG--a display of the electrical activity occurring in about one-millionth of the total of 20 to 40 billion neurons in her brain. It's magic.

No longer is the skull a black box, its clockworks invisible, as it was to Sigmund Freud, Carl Jung, and the seminal thinkers and clinicians who have shaped 20th-century psychotherapy. For the past decade, in well-funded university neuroscience laboratories from Boston to Madison to San Francisco, the black box of the skull has been opening and spilling out diamonds. And in offices across the country, therapists today are struggling to make sense of this treasure.

What practical difference does it make to the average therapist that happiness can not only be intuited from a smile, but can be viewed on a home computer as an EEG pattern of moderately quick and intense neuroelectrical firings behind the left temple and forehead? That different forms of depression don't look alike in brain scans or on EEGs, and that some are characterized by slower bioelectrical activity on the left front of the brain than on the right? That feelings of compassion are no longer merely a religious ideal, but have been recorded as rapid brain waves coursing in the left foreheads of Tibetan Buddhist monks who have meditated intensely for decades?

Here, in this rented room, the demarcations between the psychological and the neurological are melting. With the help of a couple of laptops and a $5,000 computer program, Marcia Lipsky's skull is thinning like an eggshell before our eyes--sensitive, vulnerable, semitransparent.

In one wiggling line on the laptop screen, we can see some of her neurons firing in the rapid patterns associated with tension, while on the next band up, other brain cells fire at the moderate speeds associated with relaxed alertness, and on a third band, still others fire in the slower rhythms typical of withdrawal, depression, and daydreaming. We see through a glass darkly. We don't entirely know what to make of what we see, but we see something.

Marvin presses another computer key, and on a second linked laptop, a yellow Pacman-like face appears. For the next six minutes, Marcia, without moving a muscle, will try to keep Pacman running through a maze, simply by firing her neurons fast enough to make the computer beep. When she's too tense, the beeping stops and Pacman goes dark. When she withdraws or daydreams, too many of her brain waves enter the slow, theta range (firing only four to seven times per second), and the beeping stops again. But the laptop is configured so that when she's in a sweet spot--calm yet focused, with neurons firing away on the right side of her brain at 12 to 15 times per second--Pacman gobbles away and the beeping is continuous. At tables all around us, other therapist-guinea pigs are staring into similar screens, and the air fills with a syncopated, off-rhythm chorus of electronic beeps.

We're doing more than just looking into Marcia's brain--we're resetting its inner clockworks. Neurons close to the surface of her skull will, we hope, come to fire in slower, calmer rhythms. They, in turn, should entrain other neurons deeper in her brain, relaying their calming influence from her cortex to her thalamus, which helps govern physiological regulation. The fleeting, repeated, bio-electro-chemical patterns of neural functioning that Marcia calls mild anxiety--once thought to be hard wired by temperament, early childhood development, and fate--are turning out to be malleable after all.

Our hope is that after just six minutes of training, Marcia will feel at least temporarily less anxious--without a DSM-IV diagnosis, a massage, a few minutes of meditation, a shot of Jack Daniels, or any other mood-altering technique of East or West. We'd like her to be able to sleep better and worry less.

We're exploring a new pathway to healing. We aren't viewing her anxiety hydraulically, as Freud did--as pressure that needs releasing through talk; nor as a chemical imbalance that needs carpet-bombing with Zoloft; nor as the product of distorted cognitions that need challenging. Instead, on the basis of a 14-page questionnaire she filled out, we're thinking of her as "overaroused" and are trying to teach her brain to reregulate itself at its most basic, cellular level.

Our healing technology isn't the imperfect body and soul of a therapist or meditation master, both of whom, in slow, time-tested ways, attempt to teach the psyche self-regulation. We are diving down a new rabbit hole into the psyche. We are early adopters of a wordless, computer-to-human therapy--a natural fit for a culture in love with iPods, GameBoys, and wired isolation. Our therapeutic tools are an electrode, some wax, a software program called the EEGer, and two Toshiba laptops. We've come a long way from Freud's couch.

The six minutes are up. Marcia pushes away from the table and stands up, her forehead knotted, her cheeks pale. She pulls the electrode off her scalp and unclips her ears. She doesn't feel better, she says. She feels sad. She feels worse. All around the room, the beepings are tailing off as the exercise ends and low, murmured reports from other guinea pigs--some pleased, some disappointed, and some perplexed--take their place. From the table behind us, I can hear a hospital-based psychologist say that the chronic pain she's had in her knees since the age of 19 has disappeared, at least for the moment.

We're groping and blundering in the dark, tapping along the shadowy wall of a cave with our canes. We're sailors jumping on board with Columbus, sketching new maps as we sail into regions marked, "Beyond, There Be Monsters." Welcome to garage brain science.

The Origins of Neurofeedback

Neurofeedback is not new. It was first explored in the late 1960s, decades before the laptop computer, by psychologists who used big, expensive, primitive EEG feedback machines to help subjects generate more of the slow, regular, alpha brain waves characteristic of blissful states of meditation. At the same time, in southern California, a hardheaded neuroscience researcher named Barry Sterman (now retired from UCLA's school of medicine) was accidentally discovering that generating brain waves in slightly faster rhythms could do something perhaps more miraculous: it could make the brains of cats highly resistant to epileptic seizures.

Sterman wasn't a therapist. He had no interest in altered states. He was curious about the brain mechanisms involved when behavior is inhibited. In 1965, in his lab at the veterans' hospital in Sepulveda, California, he trained 50 cats to wait until a tone sounded before they pressed a lever and got a ladle of milk. The cats became physically relaxed but mentally alert, as though crouched motionless in a garden waiting to pounce on a mouse. Their EEGs--recorded along the strip of their skulls where Alice in Wonderland wore her headband--showed odd, spindlelike tracings, indicating that clusters of the surface neurons were firing synchronously in short, repeated bursts. If you could have heard them, they'd have sounded like mini-drumrolls or brief surges of rain hitting a window at about 12 to 15 times per second, punctuated by intervals of silence. Sterman named this frequency, which is faster than alpha rhythms, Sensory Motor Rhythm, or SMR.

In his next experiment he trained the cats to generate SMR at will, for hours on end, rewarding them with milk flavored with chicken broth whenever their EEGs displayed it. He published the results, intriguing but of no obviously earthshaking significance, in Brain Research in 1967.

Sterman's federal funding for this research later dried up, possibly because alpha-wave biofeedback researchers were viewed by federal bureaucrats as blissed-out ninnies. So, in a fusion of rocket science and brain surgery, Sterman moved on to investigating the neurological effects of toxic rocket fuel. (The research had its genesis in fears that the early astronauts, who'd reported seeing South Sea islanders waving at them like sirens, were getting hallucinations from exposure to rocket-fuel fumes.) On a contract from the Defense Department, he injected monomethylhydrazine into 50 lab cats and recorded their EEGs while they panted, drooled, and had epileptic fits. As described in Jim Robbins's 2002 book, A Symphony in the Brain , most of the cats had seizures within an hour of being injected, and some died soon afterward. But seven cats held off seizures for more than two hours, and three had no epileptic seizures at all. When Sterman went back over his records, he discovered that the seizure-resistant cats were the ones he'd trained earlier to generate Sensory Motor Rhythm.

That discovery tantalized him. Just exactly what had happened in those cats' brains? How had a low-key, noninvasive, behavioral intervention--training brain waves with a milk reward--made cats capable of resisting epileptic seizures? To understand how earthshaking this was, imagine the healthy brain as a huge sports stadium where clusters of neurons sit in the bleachers playing millions of semi-independent versions of the child's game of gossip, whispering messages to one another down interlocking daisy chains. In an epileptic seizure, ever-growing numbers of those neurons stop passing messages critical to body functioning and join instead in a slow, synchronized version of The Wave.

The brain-wave training had somehow taught the cats' brain cells not to take up The Wave, even when awash in an excitatory poison. An intervention so simple and subtle that even a cat could do it--involving no drugs, therapy, or surgery--had changed how neurons communicated, possibly even rejiggering their structure at the cellular level. It was early proof of what scientists now call neuroplasticity--the brain's ability to reshape itself physically.

If a machine could modulate the brain waves of cats, what could it do for humans? Five years later, Sterman hooked up a severely epileptic Veterans Administration lab tech to a clunky EEG biofeedback device that blinked a green light at her whenever her brain waves fell into SMR. After 24 sessions over three months, the tech, Mary Fairbanks, reduced her thrice-monthly seizures virtually to zero, recovering enough to get a driver's license.

Fairbanks was only the first epileptic to improve. According to a survey of the scientific literature by Sterman published in Clinical Encephalography in 2000, at least 166 medication-resistant epileptics have since been trained with neurofeedback, reducing their seizures on average by 50 percent.

If brain-wave training could modulate epilepsy, how about another presumably hard-wired impairment--AD/HD? In 1976, a psychologist who'd worked with Sterman named Joel Lubar, now at a lab at the University of Tennessee, improved the school performance of an 11-year-old boy with AD/HD by hooking him up to an EEG machine that rewarded him for reducing his overabundance of slow, daydreamy brain waves in the theta frequency range (4 to 7 firings per second--about the speed of a pheasant beating its wings).

Lubar saw true AD/HD as a purely neurological problem. He conducted his research carefully, screening out kids with concurrent depression or anxiety. Over the next three decades, he and other researchers published dozens of studies, describing successful, simple, systematic neurofeedback training with more than 1,000 AD/HD children. Although only one neurofeedback study was a gold-standard, controlled, double-blind study, the others--using control groups, but not double-blinded--suggested that, in the short term, neurofeedback improved the children's behavior and school performance about as well as Ritalin. In the 1980s and 1990s, at the height of the Prozac and Ritalin crazes, only a handful of people noticed.

In longer-term studies--all performed by proponents of the new technology--neurofeedback frequently outperformed drugs. In 2002, for instance, in the largest controlled-group study conducted so far, psychologist Vincent Monastra of Binghamton University in New York compared 51 AD/HD children receiving a Cadillac package of treatments (stimulants, individualized school help, parenting education, and a six-month course of neurofeedback) with 49 kids in a control group, getting the same package without the neurofeedback. Both groups did equally well in the short term, improving behavior at home and attentiveness in school. But in a follow-up study three years later, only neurofeedback's effects persisted after medication was temporarily withdrawn. Even more tellingly, 80 percent of the neurofeedback group had reduced their dosages of stimulant medication by at least half in the intervening three years, while none of the control group had reduced their medications, and three quarters had increased their dosages.

Powerful evidence. But therapeutic revolutions--especially ones requiring expensive equipment and nerdlike technical skills miles outside the average therapist's comfort zone--need more than scientists to become known. They need explorers, promoters, and innovators--Columbuses, P.T. Barnums, and Thomas Edisons. They need word-of-mouth buzz, training programs, and the cash to develop them.

Sterman and Lubar could provide none of these things. The National Institute of Mental Health and the pharmaceutical companies had no interest. So neurofeedback slipped out from under the laboratory door on its own, like a purloined spell.

Living With AD/HD

I have a confession to make: I didn't pursue this story strictly out of journalistic curiosity. I was hoping that neurofeedback might help me, where years of psychodynamic therapy, seven months in a Buddhist monastery, countless hours in self-help groups, and even a two-week experiment with Ritalin had failed.

All my life, I've collected ribbons and demerits. I learned to read when I was 4, edited my high school literary magazine, aced my SATs, and squeaked into a competitive New England college. Yet, since the day I lost my first mitten, I've sensed I wasn't playing with a full deck.

My mother called me scatterbrained. My father pulled out his hair. My French teacher called me an underachiever and once held up a messy paper I'd labored over, saying, "This oozes 'I don't care.'" Impulsive, disorganized, and endlessly procrastinating, I swam through life in a flotsam of pinned-up hems, minor car accidents, forgotten appointments, lost sweaters, exasperated tax accountants, and puzzled friends. I packed for trips at the last minute, got lost for hours in newspapers I didn't want to read, blurted out things I later regretted, and got breathless and dizzy at even the prospect of assembling an Ikea bookcase.

Spinning through my days, I felt like a butterfly tethered to a concrete block. Some dreams, whether writing a book or just keeping my bedroom neat, seemed to be forever just out of reach. I wanted to Photoshop my personality. I wanted to be me without the angst.

So, late last winter, I began driving 75 miles from my home to the toy-filled offices of Mark Steinberg, an educational psychologist in San Jose, California, and coauthor of ADD: The 20-Hour Solution . After running me through a battery of neuropsychological tests measuring concentration and attentiveness (I scored execrably on both dimensions), Steinberg devised a neurofeedback protocol for me, my own custom recipe. He'd give 9 minutes of alertness brain training by putting an electrode on the left side of my head--the seat of engagement with the external world--encouraging my brain waves to fire there at 15 to 18 times per second. Then he'd switch the electrode to the more nonverbal, mood-regulating right side of my head for 21 minutes of calmness training, encouraging slightly slower, SMR brain waves.

The left-brain training would rev up the more cognitive side of my brain and help my inattentiveness--a symptom of neurophysiological underarousal, as is mild depression. The right-brain training would mellow out the hemisphere specializing in mood regulation and tone down my impulsivity (a sign of overarousal). So, with an electrode pasted to my left scalp, I sat back in a leather recliner. A technician hit some keys, and I looked at a video screen showing the white wake of a boat stretching toward a brown volcano on the horizon.

When I was in the right zone, the computer beeped, I got a point, a star appeared in the video sky, and a wide strip of white spread toward the horizon. Sometimes the screen fell silent; at other times, I produced a river of continuous beeps. Whenever I earned 500 points, the volcano released a pretty cascade of colored balls.

On the first day, I hunched forward in the recliner, determined to succeed. I stared at the computer screen with narrowed eyes, afraid I'd miss something. The beeps hiccupped on and off like a car starting up on an icy morning. Then I consciously soft-focused my eyes and relaxed my clenched hands, and the beeps picked up.

In the next couple of sessions, I noticed that when the beeps stopped, I was usually monitoring and grading my performance. In time, I somehow monitored myself less, and got more beeps. After sessions four and five, I left the office feeling calm and buoyant. The long drive home was a breeze, even though I missed one exit and had to loop back. As I passed by San Francisco Bay, its gun-metal waters looked extraordinarily vivid.

My shift in mood was so palpable that my mate, Brian, noticed it immediately when I walked in our door. I touched his hand and, for the first time since we'd met, mine was warmer. I'd felt calm and aware after a seven-day meditation retreat in the past, and exhilarated after a one-mile swim. But mostly I'd oscillated between two modes--alert-but-clenched or relaxed-but-in-a-dream. I hadn't known how to be calm and alert at the same time, and I hadn't even considered that possibility as a goal. This stuff works, I thought. It isn't rocket science. Why isn't there a room of these machines in every school!?

To widen the research sample beyond my own experience, I recruited two friends, both self-diagnosed with ADD, to be fellow guinea pigs. One was Patrick Dougherty, a Minneapolis psychotherapist who'd taken the anti-AD/HD drug Strattera, with great benefit, but had had to give it up because of side effects. The other was my younger brother, Jonathan, a scattered, talented mechanic who lives in a trailer in the Southern California desert, surrounded by broken-down vehicles and half-finished projects, dreaming of designing custom cars from scratch, but barely making the rent.

All my adult life, I've stood on the sidelines, yearning to help or change my brother, much as I've wanted to change myself. When I told him that a neuropsychologist named Christine Kraus in nearby Canyon Lake was willing to give him 10 free sessions, Jonathan, a therapy virgin, shrugged and agreed. His last job, as a $10-an-hour truck driver, had ended in November 2004, and he was humping along, trying to start an auto-body shop in a rented barn with sweat equity, salvaged wood, debt, side jobs, junk, and dreams. "I know I'm smart, but my life isn't getting out of first gear," he told me on the phone. "You and I tie our shoelaces together and try to dance ballet. We're legends in our own bathroom mirrors."

Out of the Laboratory

In the 1970s, one of the few people intrigued by Barry Sterman's research was Margaret Ayers, an idiosyncratic young graduate assistant working in his lab. It was she who first smuggled neurofeedback out the laboratory door. In 1975, she secretly persuaded one of Sterman's technicians to build her an EEG feedback machine and lease the contraption to her. Much to Sterman's disgust, she then set up her own unsanctioned, one-woman show in an office on Wilshire Boulevard. The genie was out of the bottle, and nobody could stuff it back.

Ayers mostly specialized in brain injury. Desperate people, many in wheelchairs, found their way to her door. She taught them to inhibit the slow waves that are signatures of brain injury and to amplify production of beta waves--a slightly faster speed than Sterman's Sensory Motor Rhythm. Many of her clients reduced their muscle tremors or began to speak or feed themselves. Word spread. Ayers moved to a charming and eccentric building on Beverly Hills' fancy Canon Drive that had once housed Will Rogers's film studio. She works there to this day, enjoying a powerful but sub-rosa reputation as a miracle worker to ordinary Angelenos and the occasional movie star.

Ayers's results, dramatic though they sometimes were, drew little attention from established psychology, neurology, or medicine. An unsanctioned irregular, she was part of no established professional community, practicing a hybrid, orphan discipline, with no credentials beyond voluntary biofeedback certification and her own growing reputation. Had she not crossed paths with a distraught and equally unconventional couple named Siegfried and Sue Othmer in 1985, it's likely that neurofeedback would have remained a curiosity, a sort of therapeutic Veg-O-Matic, promising wonders but practically unavailable outside a few university labs and a quirky office in Beverly Hills.

The Othmers didn't come to Ayers to sell themselves as promoters. They came because they were contemplating putting their 17-year-old son, Brian, into residential treatment. Brian had been deprived of oxygen at birth and was born blue. In the Middle Ages, he'd have been called possessed. Today he'd probably be labeled bipolar or as suffering from a combination of Tourette's disorder, epilepsy, Asperger's disorder, learning disabilities, and AD/HD. He was on high doses of the antiseizure drugs Dilantin and Tegretol. He didn't listen in class or complete his homework. As a child, he'd wandered the hills, climbed cliffs, barked like a dog in his sleep, kicked holes in doors, and beat up on other children without warning or explanation. He'd said he wanted to commit suicide, that he was "evil" and a "warlock," and would go to prison when he grew up.

He began neurofeedback training on Ayers's machinery in March 1985 and was taught to inhibit his overabundance of slow, theta brain waves. By May, he'd stopped beating up his younger brother and was finishing his homework for the first time in his life. In June, his family physician reduced his medications and said he appeared to be "outgrowing" his learning disabilities. He still had many problems and took Tegretol, but in the fall of 1986, he went off to college--something his parents had thought would never happen.

Siegfried Othmer, who had a Ph.D. in physics and worked in the defense and aerospace industries, recalls bringing Brian to Ayers's office, watching her patients go in and out, and thinking he was looking at the equivalent of a wall of crutches at Lourdes. He and his wife, Susan, who'd done graduate work toward a Ph.D. in neuroscience at Cornell, decided to bring this neurological Lourdes further into the mainstream, first in collaboration with Ayers, and then despite her.

Over the next two decades, the couple ran up credit-card debt, spent a family inheritance, found small investors, and hired computer-software designers to create sophisticated EEG-feedback programs that looked like video games. The Ayers-Othmer collaboration quickly broke down, and much to Ayers's disgust, Sue Othmer began treating acquaintances on a new prototype, charging $40 for the sessions she held in her guest room in the San Fernando Valley. Ayers, who'd quietly patented the new equipment and software, sued for patent infringement.

Susan Othmer, like Ayers before her, soon developed a reputation as an excellent, intuitive, outsider clinician. Unshackled by the conventions of university-based research, she tackled just about anything--PMS, depression, insomnia, migraines, phobias, autism, manic depression, and panic disorder. At the time, many researchers assumed that semiautonomous neural circuits separately regulated emotions, thinking, and physiological functions. Sue Othmer assumed no such firewalls.

Instead of pigeonholing problems via the DSM grid, Othmer first sorted out whether her client was overaroused, underaroused, or unstably aroused--neurophysiological categories that make a hash of 20th-century distinctions between the physical, emotional, cognitive, and neurological. Asperger's, autism, panic disorder, and trouble falling asleep were lumped together as expressions of overarousal. Depression, perfectionism, and trouble staying asleep were characterized as signs of underarousal. Bipolar disorder, migraines, and epilepsy were slotted as manifestations of unstable arousal. This was a new form of clinical categorization.

At first, Susan Othmer's treatments followed in the conservative footprints of Sterman, Lubar, and Ayers. Like them, she placed her electrodes at the midline of the head or else along the sensorimotor strip, which runs above the top of the forehead. She revved up the underaroused with left-brain training in the beta brain-wave frequency range and soothed the overaroused with right-brain training in slower Sensory Motor Rhythm.

But soon, she struck out for unmapped territory. Cautiously, she began moving electrodes to other spots on the scalp, playing with frequency-reward bands, and asking clients how they felt. One day, she placed an electrode on the left side of a migraine sufferer's head. The migraine "jumped" to the right side. She moved the electrode to the right, and the migraine jumped back again. She tried putting an electrode on each side of the head and configuring her computer so that it integrated data from both hemispheres. The migraine stopped. The closer she moved her electrodes down toward the ears--closer to the primitive, emotional, limbic system, packed in deep in the center of the skull--the more powerful, stabilizing, and physiological the effect became.

By then, the Othmers' business--named EEG Spectrum--had mushroomed and moved into rented offices. Margaret Ayers's lawsuit against them was settled through arbitration in 1991, the same year the Othmers' son Brian, having apparently suffered a seizure in his sleep, died in his bed in his college dorm.

The Othmers forged on. By 1995, their clinic occupied a suite of offices, employed two technicians working under Susan, and delivered some 4,500 neurofeedback sessions a year to more than 100 clients. More important, they'd become the Johnny Appleseeds of neurofeedback. They talked up neurofeedback on TV shows, trained others, spoke at support groups for parents of learning-disabled children, and presented papers at the Winter Brain Conference in Palm Springs and other professional gatherings.

By the mid-1990s, when the affordable personal computer and the video game met the Decade of the Brain, the Othmers had helped catalyze a nationwide community of sometimes groundbreaking, sometimes chaotic and haphazard, clinical experimentation. They'd trained therapists by the hundreds--even though, as Siegfried Othmer later put it, for most therapists, learning about neurofeedback is "something like eating for the first time with chopsticks."

Some of the Othmers' trainees were psychologists and psychiatrists with teaching positions at major universities. Others were clinicians with little background in neuroscience, who emerged from four-day trainings with their electrodes and expensive new EEG software programs in hand, eager but bewildered. Among the bewildered was John Demos, a masters-level counselor in Brattleboro, Vermont, with a specialty in integrated medicine, post-traumatic stress, and biofeedback. Trained in 2000, he had a few inexplicably miraculous successes, including several with clients with PTSD. But his overall success rate hovered around 30 percent--little better than that of placebo.

"The education I'd received left me with one question: why am I doing this?" says Demos, who's since written Getting Started with Neurofeedback , a practical, neuroscience-based primer he wished he'd had when he began. "One week, clients would say they felt better, and the next week they'd say they were feeling worse. It was pure guesswork. I was moving sensors from place to place, chasing all over the brain."

Demos has since taken up a more systematic and technological approach, starting with taking a quantitative EEG (qEEG)--a computerized innovation that reads brain function simultaneously at 21 different electrode sites on the skull and compares them to a database of "normal" brains. Demos uses the subsequent "brain map" to decide where to place his electrodes.

Hit-and-miss or not, the miracles kept on coming. Psychologist Ed Hamlin took neurofeedback back to his Pisgah Institute group practice in Asheville, North Carolina, in 1998 and began experimenting. He and a fellow Pisgah partner, psychiatrist Stephen Buie, eventually hit on a protocol that stabilized more than 30 severely manic-depressive clients who'd been repeatedly hospitalized, despite massive doses of anticonvulsant and antipsychotic drugs.

Before neurofeedback, Hamlin said, his work with his patients had been pretty much limited to getting them to keep taking their meds, no matter how zombielike they made them feel. At best they stabilized on the drugs at what Hamlin calls "a sort of negative static hum," rating themselves at a zero on a -5 to +5 mood-rating scale.

After neurofeedback, the clients reported they'd stabilized at +1, a mildly positive state. "The results are so unrealistically positive that I know we sound like an infomercial sometimes," Hamlin says "Before, we were teaching these clients coping strategies. Now we're actually treating the disorder. We're doing something that directly impacts the neurophysiology of their problem." The results are so universally positive, Hamlin adds, he now considers it "almost negligent" not to treat bipolar patients with neurofeedback.

In 2000, psychologist Laurence Hirshberg, an assistant professor in clinical psychiatry at Brown University, returned from neurofeedback training to a Providence, Rhode Island, psychology practice full of children with AD/HD and autism spectrum disorder. He now supervises six technicians who deliver 105 treatment hours per week at his office at 13 neurofeedback stations. Another 16 families, many with autistic children, do neurofeedback training at home under Hirshberg's supervision, on leased machines.

"Part of the problem with this field is that the stories are so amazing that nobody believes them. I'm trying not to sound like a wild man," says Hirshberg, who guest-edited a major positive review of neurofeedback research for the January 2005 volume of Child and Adolescent Psychiatric Clinics of North America.

The treatment, Hirshberg adds, has transformed his understanding of the neurological substrates of some disorders he once considered primarily psychological. "You take a child with reactive attachment disorder who's struggled for years with expressing any feeling of warmth and affection. You do five or six [neurofeedback] sessions, and, suddenly, the parents report, 'O my God, he's showing warmth and affection.' He sits next to them on the couch, he smiles.

"Or take a child with autism. A mother may report something as mundane as her child's recognizing that she's carrying bags of groceries and holding the door open for her. This relatively innocuous intervention certainly suggests there's a primary contribution from the brain."

The View from the Trenches

The longer a therapist stays with neurofeedback, the more complex their view of the technology becomes. Therapist Sebern Fisher, for instance, was an early adopter who took neurofeedback training from the Othmers in 1995 and returned to Northampton, Massachusetts, to a private caseload of trauma survivors. She'd tried teaching them self-regulating strategies drawn from Dialectical Behavior Therapy, but she'd often run up against their ingrained physiological reactivity. That changed when she added neurofeedback. One of her clients, a talented young teenager with a childhood-abuse history and Asperger's disorder, had no friends, had been hospitalized with bulimia, and was prone to violent outbursts, in which she threw things at walls. Over several years of neurofeedback and conventional psychodynamic therapy, the girl developed the capacity to empathize with others, stopped her violence and bulimia, and went off to a demanding college.

Over the years, Fisher, one of the consortium of therapists who bought the Othmers' EEG Spectrum company out of bankruptcy in 2002, came to believe that neurofeedback could help rewire brains that had failed, because of neglect or abuse, to develop crucial, early neural connections in the frontal cortex, and could reregulate primitive brain parts deep in the skull, like the fear-driven amygdala. But she soon found that neurofeedback was a double-edged sword. Placing electrodes on both sides of the head simultaneously made unstable people more stable, for instance. Too much of it made them rigid. A little left-side training made the depressed more confident. Too much made them sociopathic.

Fisher's young client with Asperger's, for instance, started stealing things from her boarding-school dormmates about two years into her neurofeedback training. When Fisher finally found out (the girl kept it from her for months), she stopped left-brain training, and got the girl to go to the principal and admit what she'd done. Fisher's bearded and respectable husband John, after doing left-side training, found himself zipping in and out of traffic one night, self-righteously pursuing a 19-year-old who'd cut him off, flipping the boy the finger and intending to teach him a lesson--the kind of thing John hadn't done in 30 years.

Sebern Fisher became a Cassandra at conferences, warning anyone who'd listen that good neurofeedback should always be held within a container of psychotherapy and human relationship. Someone--hopefully someone with some wisdom--had to decide which brain changes to target, and in what order. Someone had to notice when a change made a client feel better but act worse. Someone had to notice when an excess of virtue became a vice.

"Something Just Went Snap"

In April, after 10 neurofeedback sessions with neuropsychologist Christine Kraus, my brother called and said, "Something just went snap." He'd awoken alert and had functioned all day on a single cup of coffee, rather than downing four or five cups without ever really getting out of a fog. He was less anxious. He could go to the next room for a tool and come back with it, instead of getting lost in another half-finished project. The effect held the next day, and the next, and the next.

He took some of the junk surrounding his barn to the dump, earned cash selling scrap metal, and worked a shift as a limousine driver. After barely having opened a book in 15 years, he started spending an hour a day poring over a complex economic and military history of World War II. He talked to me more about how he planned to cover his monthly expenses and less about a distant, glorious future.

Then, in mid-May, an axle on his truck broke, he ran out of money, and he fell into what he called a "reality-based" depression. My heart sank. He kept going to neurofeedback (our mother paid), but the depression didn't lift until mid-June.

I'd hoped he'd magically emerge from his desert chrysalis, out of debt, with steady, well-paying, absorbing work; perhaps even with a girlfriend and a home mortgage. But what has emerged instead are small mercies. The story he tells about himself is less self-critical, less defensive, more hopeful.

"The soil here is decomposed granite," he said after his depression lifted and his alertness returned full force. "If you put grass down, it just doesn't grow, unless you first lay down manure and wood chips. When I tried [to change my life] before, it was like trying to grow something in barren soil. You can read a book on time management, but if your head's a paint-mixer, what difference can it make? This neurofeedback is doing something on a root level that might make a difference. I know now that there's something wrong in the wiring. It's a motherboard problem--and it's repairable."

In Minneapolis, meanwhile, clinician John Anderson, a neurofeedback trainer for Stens Corporation (one of several commercial rivals of EEG Spectrum), recorded a EEG of my friend Patrick Dougherty's brain. Then he placed an electrode on a spot under Patrick's right eyebrow. Within three to five minutes of training using a highly sophisticated neurofeedback computer system made by the Lexicor corporation, Dougherty felt calmer. Calmness pervaded his life, pooled, swelled, and spilled over. He stayed behind a truck in busy traffic for six blocks rather than cutting in front to save a millisecond before parking. Within four weeks, his scores on the IVA (a test of variable attention) went from highly impulsive and inattentive to the normal range.

He reorganized a "chaos cupboard" of accumulated junk at his home and filed six months' of paperwork piled on his office filing cabinet. He felt more present, more thoughtful, and less impulsive with his clients, and they noticed the change. Navigating a difficult divorce, he didn't spin out in worst-case scenarios and often found a smile on his face. "I don't get as shook up, I don't get as mad--I don't seem to have access to it," he reports. "But what I do have access to is happiness. I'm happier, more peaceful, with a quiet happiness--a steadiness that brings me pleasure."

As for me, I finished an article two hours before a deadline rather than one hour late. I felt more confident and decisive. I slept more deeply. I assembled tax records for my accountant two weeks before April 15, rather than six weeks after. I went to the airport bringing a small rollaboard of perfectly matched clothes that I'd packed two nights earlier, instead of lugging on three heavy bags packed in a panic at midnight the night before the flight. Then I started waking repeatedly at night again, with worries cycling through my head, feeling more self-doubting and obsessive than I'd ever been.

When Alice fell down the rabbit hole into Wonderland, she discovered a huge mushroom and broke off a piece with each hand. When she nibbled from the right-hand chunk, she shrank so fast she hit her chin on her foot. When she took a bite from the left, she grew so tall she could barely see her own shoulders. Only by repeatedly overshooting the mark did she get herself to her right size again. My experience of neurofeedback has been a bit like that.

In the course of this article, I was offered free neurofeedback sessions by many of the people I interviewed. Each had a favorite electrode placement and reward frequency--a personal signature, like a family's special recipe for pecan pie or winter squash soup. One tried left-brain training followed by right-brain training, to soothe my mild depression and anxiety; another put an electrode just above each ear at the same time for neurophysiological stabilization; another plunked two electrodes just back of my forehead to improve my planning and decision-making; another tried two electrodes toward the back of the skull, close to my brain's parietal lobes, to improve my clumsiness, key-loss tendencies, and weak spatial orientation. (My handwriting got better.) Like an impulsive tourist at a gelato stand handing out free samples, I had trouble saying no. And I paid a price.

After one session, I spent the better part of three days in a backyard hammock, as involuntarily relaxed as someone on barbiturates. My sleep got better, and then worse. Another time, I chewed up an enormous wad of gum like someone on methedrine. Why had I let people I hardly knew put a Mixmaster into my brain? At the start, I'd assumed this wasn't rocket science. Now I realized it is a kind of brain surgery.

I write these words after 25 neurofeedback sessions--15 short of the 40 recommended for lasting change. Using equipment borrowed from EEG Spectrum, I still go to our spare bedroom two or three times a week and stick electrodes onto my head, following protocols prescribed via e-mail by John Anderson in Minneapolis, who's radically helped my friend Patrick Dougherty.

I feel less like a butterfly tethered to a rock. I think more about the next five minutes and less about the next five years. I say fewer things I regret. My scores of impulsiveness have normalized, and my scores of inattentiveness nearly so. Brian and I spent the last couple of weekends assembling and installing an entire wall of Ikea bookcases, and I never once felt overwhelmed or dizzy. My treasured books, hidden in a closet since I moved in four years ago, are now finally on display.

By silently looking at a computer game, without any form of human interaction, I had changed quirks that hadn't responded to meditation or to scrutiny of my subconscious motives. In the grand scheme of things, the improvements may be trivial neurological fixes to anyone but me. But neurological changes don't exist in a vacuum: they set off changes in a wider world. Having my books out has made me more at home in this house and changed the way I'm perceived here. I speak up more. My relationships, and the stories I tell about them, are shifting, too.

I'm grateful for this, and surprised by the emotional sea changes that I hadn't bargained for. I rarely feel mildly depressed anymore. I'm warmer, more flexible, and more forthright with my stepsons. I worry less and express my love for Brian more freely. But I'm not "there" yet--wherever "there" is. I'm still waiting for all the cherries to line up in the slot machine and deliver the jackpot.

At the dawn of the 20th century, just before World War I, Freud speculated about the contents of the black box we call the brain. To a society that still had faith in the power of human rationality and probity, he told a new story: there are aspects of the self outside conscious awareness, and a "talking cure" can help reshape them. Now that we know more about the shifting infinitude of the neurochemicals and electrical pulses that make up the brain and nervous system, his details and logic (such as the notion that depression is anger turned inward, or that nothing is an accident) seem hopelessly formulaic. But his story shaped how 20th-century human beings saw themselves. It gave them hope that a person could change, when held in a net of intimate connection with a therapist. In that intimate connection, one could illuminate one's hidden symbolic life; one could speak aloud half-remembered stories of childhood and relationship that had enslaved one; one could fashion new narratives that would lead, hopefully, to a measure of emotional liberation.

Now, at the dawn of the 21st century, brain technology is allowing us to access corners of the black box that Freud couldn't even imagine. Not coincidentally, odd and apparently effective new therapies--neurofeedback, EMDR, Dialectical Behavior Therapy, Thought Field Therapy--are simultaneously gaining ground. All focus heavily on reregulating a disregulated neurophysiology. And all suggest an understanding of human identity and experience that draws little on the story- and symbol-making dimensions so essential to Freud's narrative.

Those who are informally researching neurofeedback are giving us the most subtle, highly calibrated feedback on brain processes that the human race has ever known. But we're a long way from weaving these data into a more inclusive story of psychological and human change. So far, it's clear only that the old categories--psychology, neurology, physiology, cognition, and emotion--make sense only when you're outside of the black box of the brain, imagining. But what new categories will take their place? And how will those categories interweave with notions of a good human life?

Perhaps, in a decade or so, neuroscience's discoveries will reshuffle all the categories in the DSM, making it the Diagnosistic and Statistical Manual of Emoto-Cognito-Neurophysiological Processing and Disregulation. Just as the Inuits are reputed to have dozens of words for snow, the new brain science has already pointed out the need for words to differentiate between several forms of depression that don't look alike on brain scans, and respond to different medications and neurofeedback treatments. Perhaps, on the other hand, neurofeedback will remain where it is now, somewhat outside the mainstream, practiced by a devoted coterie but dismissed as experimental by the same academic and medical authorities who once dismissed acupuncture.

No matter what happens, these new understandings--of how cellular processes of emotional regulation and disregulation profoundly shape human thought, response, behavior, and even story--are likely to continue to be almost intoxicating. Being able to tweak the activity of a pinhead's worth of neurons is remarkable. In the intoxication, it's easy to applaud the change and forget to ask whether it's good, and how it'll be used. Only wisdom can decide when a longed-for stability crosses the line into rigidity. Only the wise know when increased efficiency and confidence shade into narcissism and even sociopathy. And that is why, no matter how good the machines get, the sages and wise women of psychotherapy and religion will have a place.

Questions about narcissism and rigidity are ultimately moral questions--questions human beings have pondered since people first hung around fires together, telling folktales and epics about the hero's quest and his final return. Such questions can't be answered by machines. Actually, the ancient Greeks have already taught us that every virtue needs its constraining opposite: honesty without kindness, for example, is cruelty. Similarly, the ancient Buddhist masters warned us that each good quality has its "near-enemy": the near-enemy of even-mindedness is indifference; the near-enemy of compassion is pity. Unleavened by such traditional wisdom, neurofeedback could help shape people into ridiculous parodies of the attributes that are so revered in the 21st-century marketplace--making them hyperefficient, capable of unlimited work, and never, ever depressed or self-doubting.

In the 1930s, the blues guitarist and songwriter Robert Johnson was reputed to have gone out to the crossroads alone at night and sold his soul to the devil in return for superhuman musical talent. In legends about such Faustian bargains, the desperate trade always takes place in isolation and involves a desire for some single-pointed form of perfection, outside a larger context of human relationship. As the 21st century advances and neurotherapeutic tools become ever more powerful and efficient, we'll depend more than ever on the great wisdom traditions to keep us away from the crossroads, where we may be tempted to bargain our souls away, and to remind us of where we all came from--hanging around the fire together, telling stories.

Networker Features Editor Katy Butler was a finalist for a National Magazine Award in 2004. She's written for the New Yorker and The New York Times , and teaches memoir writing at the Esalen Institute each fall. Contact: or